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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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Related Experiment Video

Updated: Jun 22, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Recent advances in coeliac disease.

Matthew J Armstrong1, Gerry G Robins, Peter D Howdle

  • 1Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, UK.

Current Opinion in Gastroenterology
|June 17, 2009
PubMed
Summary

Recent advances in coeliac disease research highlight environmental and genetic factors. While a gluten-free diet is crucial, new treatments targeting cereal protein toxicity show promise.

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Published on: March 10, 2015

Area of Science:

  • Gastroenterology and Immunology
  • Celiac Disease Pathogenesis

Background:

  • Growing global awareness of celiac disease across all age groups.
  • Increasing recognition of celiac disease-related complications.

Purpose of the Study:

  • To critically summarize recent research advances in coeliac disease.
  • To provide an overview of current understanding and future directions in coeliac disease research.

Main Methods:

  • Review of large multicentre studies.
  • Analysis of recent findings in genetics, serology, and environmental factors.
  • Synthesis of current treatment strategies and emerging alternatives.

Main Results:

  • Environmental and non-HLA genetic factors play a significant role in coeliac disease development.
  • Negative coeliac serology in siblings indicates a very low risk of developing the disease.
  • Improved serological antibody testing enables potential community screening programs.
  • Adherence to a gluten-free diet remains essential for managing coeliac disease.

Conclusions:

  • Despite progress in genetic and immunological understanding, a gluten-free diet is the primary treatment.
  • Emerging alternative therapies aimed at modifying cereal protein toxicity are showing positive results.