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Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Related Experiment Video

Updated: Jun 22, 2026

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

An optical trapped microhand for manipulating micron-sized objects.

Graeme Whyte, Graham Gibson, Jonathan Leach

|June 17, 2009

Summary

This summary is machine-generated.

Researchers created a novel microhand using holographic optical tweezers. This system maps fingertip movements to control silica beads for manipulating challenging micro-objects like chrome particles in real time.

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Last Updated: Jun 22, 2026

Optical Trapping of Nanoparticles

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Published on: January 15, 2013

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Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities

Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities

Published on: April 22, 2013

Area of Science:

Microscopy and optical manipulation
Nanotechnology and microfabrication
Biophysics and micromanipulation

Background:

Traditional optical tweezers face limitations with scattering or light-sensitive micro-objects.
Precise manipulation of micro-scale particles is crucial in various scientific fields.

Purpose of the Study:

To develop a real-time interface for holographic optical tweezers.
To enable manipulation of micro-objects unsuitable for conventional tweezers control.

Main Methods:

Holographic optical tweezers system developed.
Operator's fingertips mapped to silica beads in optical traps.
Silica beads function as microhand fingertips.

Main Results:

Demonstrated real-time control of a microhand.
Successfully manipulated micron-sized chrome particles.
Enabled manipulation of strongly scattering and light-sensitive objects.

Conclusions:

The developed microhand offers a new method for precise micro-object manipulation.
This technique expands the capabilities of optical tweezers for challenging samples.
Real-time holographic control provides intuitive and effective manipulation.