Anticoagulant effects of a complex of high molecular weight heparin and arginine
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Updated: Jun 22, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
L A Lyapina1, T Yu Obergan, V E Pastorova
1Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov State Moscow University, Russia. lyapinal@mail.ru
Abstract:
Heparin forms a complex compound with arginine in a pure system, which was shown by biochemical methods. A method for obtaining the complex in vitro has been developed. At arginine/heparin molar ratio of 3:1 the complex exhibited anticoagulant, antiplatelet, and fibrin-depolymerization activities. High fibrin-depolymerization and anticoagulant activities were documented in the blood of animals 10 min after intravenous injection of the arginine-heparin complex, in contrast to the picture after injection of the complex components (heparin and arginine) alone.
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