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Does extreme prematurity affect kidney volume at term corrected age?

Alison L Kent1, Rajeev Jyoti, Cameron Robertson

  • 1Department of Neonatology, The Canberra Hospital, Canberra, ACT, Australia. alison.kent@act.gov.au

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 17, 2009
PubMed
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Extreme prematurity did not affect renal volume in neonates. This study found similar kidney volumes in extremely preterm infants and term-born infants at term corrected age.

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Area of Science:

  • Neonatal research
  • Renal physiology
  • Medical imaging

Background:

  • Extreme prematurity can lead to renal insults, potentially impacting glomerular number and renal size.
  • Reduced renal volume in infancy may be linked to later cardiovascular disease.
  • Investigating renal volume in preterm neonates is crucial for understanding long-term health risks.

Purpose of the Study:

  • To determine if extreme prematurity is associated with decreased renal volume.
  • To utilize magnetic resonance imaging (MRI) for precise measurement of renal volume.
  • To compare renal volumes between extremely preterm neonates and term-born infants.

Main Methods:

  • Seventeen neonates born before 29 weeks' gestation and 13 term infants were enrolled.
  • Magnetic resonance imaging (MRI) was performed at term corrected age for preterm infants and within 4 weeks of birth for term infants.
  • Total renal volume and kidney volume to weight ratio were compared between the two groups.

Main Results:

  • No significant differences were observed in weight or length between preterm and term neonates at the time of MRI.
  • Total renal volume showed no significant difference between extremely preterm neonates and term infants (p = 0.83).
  • The total kidney volume to weight ratio was also similar between the groups (p = 0.6).

Conclusions:

  • Extremely premature neonates exhibit comparable renal volumes to term-born infants at term corrected age.
  • The study suggests that renal volume at term corrected age may not be a reliable indicator of glomerular number.
  • Further research is needed to establish the relationship between renal volume and glomerular development in preterm infants.