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Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors
1Department of Pathology, Ankara University, School of Medicine, Ankara, Turkey. gulsah@gmail.com
Background/Aims:
Friend leukemia virus integration-1 expression has been shown in a variety of tumors, including vascular tumors, desmoplastic small round cell tumor, Merkel cell carcinoma, and lymphoblastic lymphoma, in addition to Ewing's sarcoma/primitive neuroectodermal tumor. The aim of the current study was to examine Friend leukemia virus integration-1 protein expression in a series of gastrointestinal stromal tumors and also to assess if Friend leukemia virus integration-1 has any role in the disease process. It is the first study analyzing Friend leukemia virus integration-1 expression in gastrointestinal stromal tumors in the English literature.
Methods:
A tissue microarray block containing 52 cases of gastrointestinal stromal tumors was done. Immunohistochemical analysis was performed for Friend leukemia virus integration-1 polyclonal antibody.
Results:
Immunohistochemically, Friend leukemia virus integration-1 was negative in all cases.
Conclusions:
Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor. We think that this protein is not expressed in gastrointestinal stromal tumors and it is not a part of the pathogenesis of this disease.
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