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Herpes simplex encephalitis with relapse.

M G Pike1, C R Kennedy, B G Neville

  • 1Hospital for Sick Children, London.

Archives of Disease in Childhood
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

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Herpes simplex encephalitis (HSE) in children can have a biphasic course, suggesting current antiviral treatments may be insufficient. A secondary neuroallergic reaction could necessitate immunomodulatory therapies instead.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Herpes simplex encephalitis (HSE) is a severe neurological condition.
  • Standard treatment involves antiviral medications.

Observation:

  • Three pediatric cases of HSE exhibited a distinct biphasic clinical course.
  • A secondary deterioration occurred after initial improvement.

Findings:

  • The biphasic course suggests potential limitations of current antiviral regimens for HSE.
  • Recurrence of viral activity or a postinfectious neuroallergic response are considered possible causes.

Implications:

  • Current HSE treatment protocols may require re-evaluation for biphasic cases.
  • Immunomodulatory treatments could be a viable alternative or adjunct therapy for neuroallergic complications of HSE.

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