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Updated: Jun 22, 2026

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells

Published on: June 17, 2008

Mitochondrial function and redox state in mammalian embryos.

R Dumollard¹, J Carroll, M R Duchen

¹Laboratoire de Biologie du Développement, UMR 7009, Station Zoologique, 06230 Villefranche sur Mer, France. remi.dumollard@obs-vlfr.fr

Seminars in Cell & Developmental Biology

|June 17, 2009

Summary

This summary is machine-generated.

Mitochondria are crucial for mammalian embryo development, impacting energy, redox balance, and antioxidant defenses. Their function is vital for preventing developmental arrest and apoptosis, highlighting their central role in early life.

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Oxygen-Independent Assays to Measure Mitochondrial Function in Mammals

Oxygen-Independent Assays to Measure Mitochondrial Function in Mammals

Published on: May 19, 2023

Area of Science:

Cell Biology
Developmental Biology
Biochemistry

Background:

Mitochondria are essential for mammalian oocyte and early embryo development.
Beyond energy production, mitochondria regulate intracellular redox metabolism and antioxidant defenses.

Purpose of the Study:

To elucidate the multifaceted roles of mitochondria in early mammalian embryo development.
To understand the impact of mitochondrial function on intracellular redox state and oxidative stress response.

Main Methods:

Analysis of mitochondrial roles in energy production, redox metabolism, and antioxidant defense.
Investigation of metabolic substrate impact (pyruvate, lactate) on intracellular redox state.
Examination of mitochondrial involvement in glutathione production and regeneration.

Main Results:

Mitochondria are central to redox metabolism, producing reactive oxygen species and providing antioxidants.
Early mammalian embryos exhibit low glucose metabolism, relying on the mitochondrial TCA cycle for reducing equivalents.
Mitochondrial dysfunction significantly impacts intracellular redox state and embryo development, increasing sensitivity to oxidative stress.

Conclusions:

Mitochondria are critical for mammalian early development, influencing energy, redox balance, and oxidative stress resistance.
Altered mitochondrial function due to pathological conditions or environmental factors impairs embryo development.
The oocyte stockpiles antioxidants, with mitochondria supporting glutathione production and regeneration for embryo survival.