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Updated: Jun 22, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
High-yielding two-step synthesis of 6,8-disubstituted N-9-unprotected purines
Nada Ibrahim1, Michel Legraverend
1UMR 176, Institut Curie, Bâtiment 110-112, Centre Universitaire, Orsay, France.
Abstract:
We report herein a convenient method for the synthesis of libraries of 6,8-disubstituted-9-H-purines in two steps, including cyclization of 6-chloro-4,5-diaminopyrimidine with various arylcarboxylic acids or chlorides, followed by S(N)Ar with amines and alkoxides or Pd-catalyzed amidations at C-6. These reactions were highly efficient and allowed the synthesis of a 32-member library of 6,8-disubstituted purines.
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