[Uro-andrologic alterations in Wolfram syndrome]

The association of diabetes mellitus, diabetes insipidus, neurosensory changes and optic atrophy is known as Wolfram's syndrome. Herein we report on a patient with hypogonadism, pyelocaliceal ectasia and anejaculation. Although associated urological disorders have been reported before, this is the first case of anejaculation coexisting in the same patient reported in the literature. The possible etiopathogenesis is discussed.