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Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

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Spectral-domain spectrally-encoded endoscopy.

Dvir Yelin, W M White, Jason T Motz

|June 18, 2009

Summary

A new spectral-domain interferometry method enhances spectrally-encoded endoscopy. This advanced imaging technique offers superior sensitivity, speed, and depth range for minimally invasive medical applications.

Area of Science:

Optical Engineering
Medical Imaging
Biomedical Devices

Background:

Spectrally-encoded endoscopy (SEE) utilizes optical fibers and wavelength division multiplexing for macroscopic imaging via miniature probes.
Existing SEE methods face limitations in sensitivity, imaging speed, and depth range for accessing difficult-to-reach internal body locations.
Conventional endoscopes have restricted access capabilities in certain anatomical regions.

Purpose of the Study:

To introduce a novel spectral-domain interferometry (SDI) detection scheme for spectrally-encoded endoscopy.
To significantly improve the performance metrics of SEE for enhanced in-vivo imaging.
To demonstrate the feasibility of video-rate, three-dimensional (3D) SEE for medical applications.

Main Methods:

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Implementation of a spectral-domain interferometry detection system for SEE.

Comparison of the new SDI-based SEE with previous time-domain configurations.

Demonstration of 3D imaging capabilities using various biological specimens.

Main Results:

Achieved over 1000-fold increase in sensitivity (77 dB) compared to prior methods.
Increased imaging speed by 6-fold, reaching 30 volumes per second.
Extended the depth range by 2-fold, up to 2.8 mm.

Conclusions:

The novel SDI detection scheme dramatically enhances SEE performance.
This technology enables real-time, 3D spectrally-encoded endoscopy.
The improved SEE system holds significant potential for diverse minimally invasive medical procedures.