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Related Experiment Videos

[Do renal vascular D2 receptors exist?].

M Barthelmebs1, J P Krieger, M Grima

  • 1Institut de pharmacologie, URA DO589 CNRS, Université Louis-Pasteur et service d'hypertension artérielle et maladies vasculaires, CHRU, Strasbourg.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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This study investigated bromocriptine

Area of Science:

  • Pharmacology
  • Renal Physiology
  • Neuroendocrinology

Context:

  • Dopamine receptors (D1 and D2) are present on renal vasculature.
  • The role of postsynaptic vascular D2-receptors is debated.
  • Bromocriptine is a D2-preferential agonist.

Purpose:

  • To characterize the in vitro renal vascular response to bromocriptine.
  • To determine the receptor subtype involved in bromocriptine-induced renal vasodilation.

Summary:

  • Bromocriptine induced concentration-dependent relaxation in isolated perfused rat kidneys.
  • This effect was comparable to dopamine but was antagonized by D2-receptor antagonists, not D1-receptor antagonists.
  • The findings suggest bromocriptine acts on postsynaptic vascular D2-receptors.

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Impact:

  • Provides evidence for the existence and function of postsynaptic vascular D2-receptors.
  • Clarifies the mechanism of bromocriptine-induced renal vasodilation.
  • Contributes to understanding renal vascular regulation by dopamine.