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Published on: June 16, 2020
Sacroiliitis and severe disability due to isotretinoin therapy
Alexander P Rozin1, Olga Kagna, Yizhak Shiller
1B. Shine Department of Rheumatology, Rambam Health Care Campus and Technion, POB 9602, 31096, Haifa, Israel. a_rozin@rambam.health.gov.il
Abstract:
We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment.
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