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Does multiple gland disease in primary hyperparathyroidism correlate with age or sex?

Denis Wirowski1, Bernhard J Lammers, Peter Pohl

  • 1Department of Visceral and Endocrine Surgery, Lukaskrankenhaus Neuss, Preussenstr. 84, 41464, Neuss, Germany. denis.wirowski@t-online.de

Langenbeck'S Archives of Surgery
|June 18, 2009
PubMed

Insights

In adult primary hyperparathyroidism (PHPT), multiple gland disease (MGD) does not correlate with age or sex unless familial PHPT is present. Familial PHPT is more common in younger patients, influencing MGD rates.

Area of Science:

  • Endocrinology
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism (PHPT) is a condition affecting parathyroid glands.
  • Paediatric PHPT patients often present with multiple gland disease (MGD), unlike adults.

Purpose of the Study:

  • To investigate the correlation between age, sex, and MGD in adult PHPT patients.
  • To determine if familial PHPT influences MGD prevalence in adults.
  • To inform surgical approach decisions for adult PHPT.

Main Methods:

  • Retrospective analysis of 465 adult PHPT patients who underwent surgery.
  • Data collected between September 2001 and December 2008.
  • Comparison of MGD frequency based on age, sex, and familial PHPT status.

Main Results:

  • Adults aged 40 or younger had higher MGD rates (22.9%) than older patients (11.0%).
  • Excluding familial PHPT eliminated the age-related difference in MGD (12.5% vs. 10.0%).
  • No significant difference in MGD frequency was observed between men (12.2%) and women (12.3%).

Conclusions:

  • In adult PHPT, MGD prevalence is not linked to age or sex when familial cases are excluded.
  • Age and sex are not indicators for specific surgical strategies in non-familial adult PHPT.
  • Ruling out familial PHPT is crucial for accurate MGD assessment in adult patients.
Abstract

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