Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and Cox...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
Weighted Mean00:57

Weighted Mean

While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Causal inference for recurrent event data using pseudo-observations.

Biostatistics (Oxford, England)·2020
Same author

Rank correlation under categorical confounding.

Journal of statistical distributions and applications·2020
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

About an adaptively weighted Kaplan-Meier estimate.

Jean-François Plante1

  • 1Service d'enseignement des méthodes quantitatives de gestion, HEC Montréal, 3000 chemin de la Côte-Sainte-Catherine, Montréal, Quebec, Canada. jfplante@hec.ca

Lifetime Data Analysis
|June 18, 2009
PubMed
Summary
This summary is machine-generated.

This study introduces a new weighted Kaplan-Meier estimate using adaptive weights for improved nonparametric inference, especially with right-censored data. Simulations demonstrate its superior performance over the standard Kaplan-Meier estimate in finite samples.

More Related Videos

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Jun 22, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

Area of Science:

  • Statistics
  • Survival Analysis
  • Nonparametric Inference

Background:

  • Inference for a single population often uses data from multiple populations.
  • Nonparametric methods are crucial for survival data, particularly with censoring.
  • Existing methods like the Kaplan-Meier estimate have limitations with certain data distributions.

Purpose of the Study:

  • To develop a novel nonparametric adaptive weights method for improved inference.
  • To enhance the Kaplan-Meier estimate to better handle right-censored data.
  • To introduce a weighted Kaplan-Meier estimate with desirable statistical properties.

Main Methods:

  • Utilizing minimum averaged mean squared error (MAMSE) nonparametric adaptive weights.
  • Defining weights based on empirical distribution function properties.
  • Incorporating the Kaplan-Meier estimate to accommodate right-censored data.
  • Developing a weighted Kaplan-Meier estimate.

Main Results:

  • The proposed weighted Kaplan-Meier estimate is smoother than the standard version.
  • The estimate converges uniformly in probability to the target distribution.
  • Simulations indicate superior finite sample performance compared to the usual Kaplan-Meier estimate.
  • A case study illustrates the practical application.

Conclusions:

  • The weighted Kaplan-Meier estimate offers a robust improvement for survival data analysis.
  • Adaptive weights effectively handle right-censored data and improve estimation accuracy.
  • This method provides a valuable alternative for nonparametric inference in survival analysis.