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Related Experiment Videos

Cognitive functioning in late Lyme borreliosis.

L B Krupp1, D Masur, J Schwartz

  • 1Department of Neurology, State University of New York, Stony Brook 11794.

Archives of Neurology
|November 1, 1991
PubMed
Summary

Patients treated for Lyme borreliosis (a tick-borne illness) show significant memory retrieval deficits. These neurobehavioral impairments persist months after antibiotic treatment, suggesting ongoing neurological effects.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Neuropsychology

Background:

  • Lyme borreliosis, a tick-borne disease, can lead to neurological issues like meningoencephalitis and encephalopathy.
  • Persistent cognitive difficulties are reported by some patients after treatment for Lyme disease.

Purpose of the Study:

  • To evaluate neurobehavioral function in patients with treated Lyme borreliosis experiencing persistent cognitive complaints.
  • To compare the cognitive performance of Lyme disease patients with that of healthy controls.

Main Methods:

  • Neuropsychological evaluation was conducted on 15 patients with Lyme disease and 10 matched healthy controls.
  • Patients were assessed a mean of 6.7 months post-antibiotic treatment for Lyme borreliosis.

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Main Results:

  • Patients with Lyme disease demonstrated significant impairments in memory tests, particularly in selective reminding measures of memory retrieval.
  • These memory deficits did not correlate with antibody titers, MRI findings, or depression levels.
  • The underlying cause of the observed encephalopathy remains unclear, though indirect infection effects or toxic-metabolic factors are hypothesized.

Conclusions:

  • Treated Lyme borreliosis can result in persistent neurobehavioral deficits, specifically affecting memory retrieval.
  • Further research is needed to elucidate the mechanisms behind this post-treatment cognitive impairment in Lyme disease patients.