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Three hypolipidemic drugs increase hepatic palmitoyl-coenzyme A oxidation in the rat
Science (New York, N.Y.)
|August 5, 1977
Abstract:
Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.