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Related Concept Videos

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

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Related Experiment Video

Updated: Jun 22, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Medical cost associated with prediabetes.

Yiduo Zhang1, Timothy M Dall, Yaozhu Chen

  • 1The Lewin Group, Falls Church, Virginia, USA. yiduo.zhang@lewin.com

Population Health Management
|June 19, 2009
PubMed
Summary

Prediabetes (PD) is linked to higher healthcare costs, exceeding $25 billion annually in the US. Early lifestyle interventions can prevent diabetes and reduce these economic burdens.

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Last Updated: Jun 22, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
04:36

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Area of Science:

  • Health Economics
  • Endocrinology
  • Preventive Medicine

Background:

  • Prediabetes affects millions of adults, representing a significant public health concern.
  • Understanding the economic impact of prediabetes is crucial for resource allocation and policy development.

Purpose of the Study:

  • To estimate national healthcare resource utilization and medical costs associated with prediabetes in 2007.
  • To determine the economic burden of prediabetes on the healthcare system.

Main Methods:

  • Utilized Poisson regression analysis on medical claims data for a continuously insured adult population (2004-2006).
  • Combined rate ratios of healthcare use patterns with national prediabetes prevalence data.
  • Calculated etiological fractions to estimate the proportion of national health resource use attributable to prediabetes.

Main Results:

  • Prediabetes is associated with significantly higher ambulatory visit rates for hypertension, endocrine/metabolic/renal complications, and general medical conditions.
  • A slight, non-statistically significant increase in visit rates for neurological symptoms, peripheral vascular disease, and cardiovascular disease was observed.
  • No significant association found between prediabetes and increased emergency visits or inpatient days.

Conclusions:

  • National annual medical costs for prediabetes exceed $25 billion, averaging an additional $443 per affected adult.
  • Prediabetes drives excessive ambulatory care use for diabetes-related comorbidities.
  • Findings support lifestyle interventions to prevent diabetes, highlighting economic benefits of delaying or preventing prediabetes.