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Updated: Jun 22, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Gene delivery for periodontal tissue engineering: current knowledge - future possibilities.

Fa-Ming Chen1, Zhi-Wei Ma, Qin-Tao Wang

  • 1Department of Periodontology & Oral Medicine, School of Stomatology, The Fourth Military Medical University, Shaanxi, People's Republic of China. cfmsunhh@fmmu.edu.cn

Current Gene Therapy
|June 19, 2009
PubMed
Summary

Gene delivery offers a novel approach for periodontal regeneration by enabling cells to produce therapeutic growth factors. This method aims to improve tissue regrowth and reduce side effects associated with traditional protein delivery for periodontal healing.

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Area of Science:

  • Periodontal regenerative medicine
  • Tissue engineering
  • Gene therapy

Background:

  • Periodontal healing involves complex signaling molecules and requires regeneration of the natural cellular microenvironment.
  • Current strategies using artificial extracellular matrix (ECM) and growth factors face challenges with protein dosage and side effects.

Purpose of the Study:

  • To review the current state of gene delivery and tissue engineering strategies for periodontal healing and regeneration.
  • To explore the potential of gene delivery as a novel approach for periodontal regenerative medicine.

Main Methods:

  • Review of existing literature on gene delivery systems and tissue engineering in periodontology.
  • Analysis of DNA plasmid-based gene delivery for sustained growth factor production.

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Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
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Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

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Last Updated: Jun 22, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
07:56

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells

Published on: November 16, 2018

  • Evaluation of combination strategies with tissue engineering for mimicking natural periodontal repair processes.

    • Main Results:

    • Gene delivery transforms cells into growth factor-producing factories, bypassing the need for large recombinant protein doses.
    • Novel gene delivery systems offer sustained and controlled release of therapeutic proteins for tissue regrowth.
    • This approach presents a versatile strategy for periodontal regenerative medicine, though still in its early stages.

    Conclusions:

    • Gene delivery, combined with tissue engineering, holds significant promise for periodontal regeneration by providing localized, sustained therapeutic agent delivery.
    • Further research is needed to develop safe and effective gene delivery platforms for periodontology.
    • This approach could revolutionize periodontal regenerative medicine by better mimicking natural biological processes.