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Updated: Jun 22, 2026

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model
Published on: April 19, 2024
Recent developments in thrombin-activatable fibrinolysis inhibitor research
Pauline F Marx1, Chantal J N Verkleij, Mercedes Valls Seron
1Department of Experimental Vascular Medicine, G1-145, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. p.f.marx@amc.uva.nl
Abstract:
Thrombin-activatable fibrinolysis inhibitor (TAFI) provides an important molecular link between the coagulation and fibrinolytic systems. In this review, recent major advances in TAFI research, including the elucidation of crystal structures, the development of small inhibitors and the role of TAFI in systems other than hemostasis, are described and discussed.
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