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Related Experiment Video

Updated: Jun 22, 2026

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction
05:07

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

Published on: March 1, 2024

Maximum recovery after knee replacement--the MARKER study rationale and protocol.

Chung-Wei Christine Lin1, Lyn March, Jack Crosbie

  • 1The George Institute for International Health, The University of Sydney, Sydney, NSW 2050, Australia. clin@george.org.au

BMC Musculoskeletal Disorders
|June 19, 2009
PubMed
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This study investigates a new rehabilitation strategy for total knee replacement (TKR) patients, combining home exercises with later, higher-intensity outpatient classes. The goal is to improve outcomes and cost-effectiveness compared to standard care.

Area of Science:

  • Orthopaedic Surgery
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Limited evidence supports immediate post-discharge outpatient rehabilitation for total knee replacement (TKR) patients.
  • Low exercise intensity tolerated early post-surgery may limit clinical benefits.
  • A novel rehabilitation strategy is proposed to address these limitations.

Purpose of the Study:

  • To evaluate the clinical and cost-effectiveness of a new rehabilitation strategy for TKR patients.
  • To compare a phased approach (home exercises followed by outpatient classes) against usual care.

Main Methods:

  • A multicentre randomised controlled trial involving 600 TKR patients in Australia.
  • Participants randomized to either the novel strategy or usual care post-discharge.

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Last Updated: Jun 22, 2026

Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction
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Early Weight-Bearing Rehabilitation Protocol After Anterior Cruciate Ligament Reconstruction

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  • Outcomes assessed at baseline, 6 weeks, 6 months, and 12 months, with 5-year follow-up for long-term data.

    • Main Results:

    • Primary outcomes: self-reported knee pain and physical function.
    • Secondary outcomes: quality of life, physical performance, and health economic data.
    • Long-term follow-up to assess sustained benefits and need for revision surgery.

    Conclusions:

    • The novel rehabilitation strategy, incorporating later-phase outpatient exercise classes, shows potential for clinical and cost-effectiveness.
    • Results can be directly implemented into clinical practice to optimize recovery for TKR patients.