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Updated: Jun 22, 2026
Murine Model of Wound Healing
Published on: May 28, 2013
[Comparison of 2-octyl cyanoacrylate adhesive and suturing for wound closure in the canine small bowel model]
Oscar Escalante-Piña1, Gabriela García-Nieto, Alma Rocío Hernández-Jasso
1Departamento de Anatomía Humana y Laboratorio de Adiestramiento e Investigación Quirúrgica, Escuela Médico Militar, México, D. F., Mexico. coep67@hotmail.com
Objective:
We undertook this study to evaluate 2-octyl cyanoacrylate (2OCA) glue and suture for wound closure in the small bowel.
Methods:
This was a comparative and experimental study. Male and female domestic dogs (n = 10) underwent a 2.0-cm small bowel closure of two wounds. All of these had closure with 2OCA in the first wound. The controls (second wound in the same dog) were closed with suture. Four weeks later the wounds were observed to evaluate the repair.
Results:
Wound closure time and macrophage count were lower with the 2OCA glue than in the suture group.
Conclusions:
2OCA glue has the strength to seal a small bowel wound. The inflammatory response to the glue is less than that of the suture at 4 weeks. These properties may make it a suitable material for replacing suture in a small bowel wound.
