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Cryofibrinogenaemia: a case report.

G D Young1, L G Cleland, J D McNeil

  • 1Royal Adelaide Hospital, SA.

Australian and New Zealand Journal of Medicine
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Cryofibrinogenemia, a rare condition, caused chronic acral ulcers in a 54-year-old man. Plasmapheresis combined with immunosuppressants effectively treated the ulcers when other methods failed.

Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Hematology

Background:

  • Cryofibrinogenemia is a rare plasma protein abnormality.
  • It can lead to vaso-occlusive phenomena and tissue ischemia.
  • Chronic acral ulceration is a potential manifestation.

Observation:

  • A 54-year-old male presented with chronic acral ulceration.
  • The patient had a confirmed diagnosis of cryofibrinogenemia.
  • Initial treatment with prednisolone and azathioprine was ineffective.

Findings:

  • A treatment regimen including plasmapheresis, cyclophosphamide, and prednisolone was initiated.
  • This combination therapy resulted in significant improvement of the acral ulcers.
  • Plasmapheresis demonstrated efficacy in managing this rare condition.

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Implications:

  • This case highlights a potential therapeutic strategy for cryofibrinogenemia-associated ulcers.
  • It underscores the importance of considering plasmapheresis in refractory cases.
  • Further research into the role of plasmapheresis in similar conditions is warranted.