Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peptidyl arginine deiminase 2 (PAD2) inhibition is associated with acute and long-term benefits in a murine model of traumatic brain injury.

The journal of trauma and acute care surgery·2026
Same author

Operational Implementation of Prolonged Field Care Kits for Large-Scale Combat Operations.

Military medicine·2026
Same author

Beyond Work Relative Value Unit: Rationale for Strategic Partnership Between Health Systems and Departments of Surgery.

Journal of the American College of Surgeons·2026
Same author

Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury.

The journal of trauma and acute care surgery·2026
Same author

Prolonged partial aortic occlusion worsens neurologic outcomes without affecting brain lesion size in a swine model of traumatic brain injury and hemorrhage.

The journal of trauma and acute care surgery·2026
Same author

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial.

Transfusion·2025
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Hypothermia in multisystem trauma.

Eugene Y Fukudome1, Hasan B Alam

  • 1Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Critical Care Medicine
|June 19, 2009
PubMed
Summary
This summary is machine-generated.

Rapid cooling (hypothermia) may protect trauma patients from lethal hemorrhage by making organs more resistant to injury. This emergency preservation technique could improve resuscitation outcomes in critical bleeding situations.

More Related Videos

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Related Experiment Videos

Last Updated: Jun 22, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Area of Science:

  • Trauma care
  • Emergency medicine
  • Physiology

Background:

  • Exsanguinating hemorrhage is a leading cause of death in multisystem trauma.
  • Hemorrhage-induced cardiovascular collapse is often unresponsive to standard resuscitation.
  • Cerebral ischemia and hypoperfusion can cause irreversible neurologic damage within minutes.

Purpose of the Study:

  • To explore hypothermia as a novel therapeutic strategy for lethal traumatic hemorrhage.
  • To determine if hypothermia can enhance organ resistance to ischemic injury during resuscitation.

Main Methods:

  • Review of preclinical data on hypothermia induction and its effects on ischemia/reperfusion.
  • Assessment of hypothermia's safety and rapidity for emergency preservation.

Main Results:

  • Preclinical evidence suggests hypothermia can be safely and rapidly induced.
  • Hypothermia demonstrates potential to attenuate the detrimental effects of ischemia and reperfusion.
  • Organ and cellular resistance to ischemic insult may be enhanced by hypothermia.

Conclusions:

  • Hypothermia shows promise as an effective treatment for lethal traumatic hemorrhage.
  • Further clinical trials are warranted to establish the therapeutic utility of hypothermia in this context.