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Updated: Jun 23, 2026

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
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Hydrogen sulfide: a new EDRF.

Rui Wang1

  • 1Department of Biology, Lakehead University, Thunder Bay, Ontario, Canada. rwang@lakeheadu.ca

Kidney International
|June 19, 2009
PubMed
Summary
This summary is machine-generated.

Hydrogen sulfide (H2S), a gasotransmitter, is emerging as a novel endothelium-derived relaxing factor (EDRF). Studies indicate H2S contributes to vasodilation, potentially acting as an endothelium-derived hyperpolarizing factor (EDHF).

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Last Updated: Jun 23, 2026

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Hydrogen Production and Utilization in a Membrane Reactor
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Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Function
  • Gasotransmitter Signaling

Background:

  • Nitric oxide (NO) is the primary identified endothelium-derived relaxing factor (EDRF).
  • Emerging evidence suggests hydrogen sulfide (H2S), another gasotransmitter, may also function as an EDRF.
  • H2S is synthesized in mammalian cells by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).

Purpose of the Study:

  • To investigate the role of hydrogen sulfide (H2S) as a potential endothelium-derived relaxing factor (EDRF).
  • To explore the mechanistic links between H2S-induced vasorelaxation and endothelium-derived hyperpolarizing factor (EDHF) activity.
  • To assess the physiological impact of H2S deficiency in the vasculature.

Main Methods:

  • Examined CSE protein expression and CBS activity in vascular endothelial cells.
  • Measured H2S production in endothelium following muscarinic cholinergic stimulation.
  • Utilized CSE knockout mice to evaluate the effects of H2S deficiency on blood pressure and vasorelaxation.

Main Results:

  • CSE protein expression and CBS activity were detected in vascular endothelial cells.
  • Endothelium produces measurable H2S upon muscarinic cholinergic stimulation.
  • H2S-induced vasorelaxation shares mechanistic similarities with EDHF.
  • CSE deficiency in mice led to increased blood pressure and impaired endothelium-dependent relaxation in resistance arteries.

Conclusions:

  • Hydrogen sulfide (H2S) is produced by the endothelium and contributes to vasodilation.
  • H2S exhibits functional and mechanistic overlap with endothelium-derived hyperpolarizing factor (EDHF).
  • Further research is needed to definitively classify H2S as a novel EDRF or EDHF.