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Updated: Aug 1, 2026
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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Coronary vasomotion and coronary flow reserve during exercise
O M Hess1, L Felder, A Gaglione
1Department of Internal Medicine, University Hospital, Zürich, Switzerland.
Basic Research in Cardiology
|January 1, 1991
Summary
New digital subtraction techniques can now measure coronary flow reserve and stenosis geometry in patients with coronary artery disease at rest and during exercise.
Area of Science:
- Cardiovascular Imaging
- Physiology
Background:
- Coronary vasomotion and blood flow are crucial for myocardial perfusion, especially in coronary artery disease.
- Assessing these parameters is vital for understanding heart function in patients.
Purpose of the Study:
- To combine quantitative coronary arteriography and parametric imaging to assess coronary dimensions and flow reserve.
- To evaluate the feasibility of these combined techniques in normal subjects and CAD patients under various physiological conditions.
Main Methods:
- Utilized digital subtraction angiography to perform quantitative coronary arteriography and parametric imaging.
- Measured coronary dimensions and coronary flow reserve in 15 patients (7 normal, 8 with CAD) at rest, during exercise, and after pharmacologic vasodilation (papaverine, nitroglycerin).
Main Results:
- Demonstrated that modern digital subtraction techniques can accurately determine both stenosis geometry and coronary flow reserve.
- Confirmed the ability to assess these parameters under resting and exercise conditions.
Conclusions:
- Modern digital angiography techniques offer a comprehensive approach to evaluating coronary artery disease.
- These methods allow for simultaneous assessment of anatomical stenosis and functional flow reserve, improving diagnostic capabilities.
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