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Updated: Jun 22, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Neopterin for risk assessment in angina pectoris
Pablo Avanzas1, Juan Carlos Kaski
1Area del Corazon, Hospital Universitario Central de Asturias, Oviedo, Spain.
Abstract:
Inflammation plays a major pathogenic role in atherosclerosis and its complications. Among the inflammatory cells that take part in this process, activated macrophages contribute significantly to atherosclerotic plaque progression, fibrous cap disruption and intracoronary thrombus formation. Neopterin, a pteridine derivative and a byproduct of the guanosine triphosphate-biopterin pathway, is mainly produced by activated macrophages. This article reviews the existing evidence suggesting an important role for neopterin as a marker for cardiovascular risk and also as a possible pathogenic factor in atherosclerosis.
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