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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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Related Experiment Video

Updated: Jun 22, 2026

Generation of Fluorescent Protein Fusions in Candida Species
09:27

Generation of Fluorescent Protein Fusions in Candida Species

Published on: March 4, 2017

[Neonatal candidiasis: therapeutic options].

F Solorzano Santos1, J Reyna Figueroa, M J Torres Munoz

  • 1Hospital de Pediatria CMN Siglo XXI, IMMS, Mexico, DF.

Drugs of Today (Barcelona, Spain : 1998)
|June 19, 2009
PubMed
Summary

Neonatal intensive care unit (NICU) factors increase the risk of opportunistic infections, primarily Candida albicans, causing neonatal candidiasis. New antifungal agents offer expanded treatment options for this serious condition.

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Generation of Fluorescent Protein Fusions in Candida Species
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Area of Science:

  • Neonatal medicine
  • Infectious diseases
  • Mycology

Context:

  • Premature infants in intensive care are susceptible to opportunistic infections due to invasive procedures, antibiotics, and parenteral nutrition.
  • Candida species, particularly Candida albicans, are the primary cause of neonatal candidiasis.
  • Commonly implicated Candida species include C. albicans, C. parapsilosis, and C. tropicalis.

Purpose:

  • To review the risk factors for neonatal candidiasis.
  • To identify the main causative agents of neonatal candidiasis.
  • To outline the available antifungal treatments for neonatal candidiasis.

Summary:

  • Diverse risk factors in neonatal intensive care units (NICUs) predispose preterm infants to opportunistic infections.
  • Candida albicans is the predominant pathogen responsible for neonatal candidiasis, with C. parapsilosis and C. tropicalis also frequently involved.
  • Recent advancements in antifungal therapies, including amphotericin B formulations, fluconazole, itraconazole, and caspofungin, have broadened treatment options.

Impact:

  • Highlights the vulnerability of NICU infants to fungal infections.
  • Emphasizes the importance of understanding Candida species in neonatal infections.
  • Informs clinical practice regarding the management of neonatal candidiasis with newer antifungal agents.