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Generation of Fluorescent Protein Fusions in Candida Species
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Generation of Fluorescent Protein Fusions in Candida Species

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[Neonatal candidiasis: therapeutic options]

F Solorzano Santos1, J Reyna Figueroa, M J Torres Munoz

  • 1Hospital de Pediatria CMN Siglo XXI, IMMS, Mexico, DF.

Drugs of Today (Barcelona, Spain : 1998)
|June 19, 2009
PubMed

Insights

Neonatal intensive care unit (NICU) factors increase the risk of opportunistic infections, primarily Candida albicans, causing neonatal candidiasis. New antifungal agents offer expanded treatment options for this serious condition.

Area of Science:

  • Neonatal medicine
  • Infectious diseases
  • Mycology

Context:

  • Premature infants in intensive care are susceptible to opportunistic infections due to invasive procedures, antibiotics, and parenteral nutrition.
  • Candida species, particularly Candida albicans, are the primary cause of neonatal candidiasis.
  • Commonly implicated Candida species include C. albicans, C. parapsilosis, and C. tropicalis.

Purpose:

  • To review the risk factors for neonatal candidiasis.
  • To identify the main causative agents of neonatal candidiasis.
  • To outline the available antifungal treatments for neonatal candidiasis.

Summary:

  • Diverse risk factors in neonatal intensive care units (NICUs) predispose preterm infants to opportunistic infections.
  • Candida albicans is the predominant pathogen responsible for neonatal candidiasis, with C. parapsilosis and C. tropicalis also frequently involved.
  • Recent advancements in antifungal therapies, including amphotericin B formulations, fluconazole, itraconazole, and caspofungin, have broadened treatment options.

Impact:

  • Highlights the vulnerability of NICU infants to fungal infections.
  • Emphasizes the importance of understanding Candida species in neonatal infections.
  • Informs clinical practice regarding the management of neonatal candidiasis with newer antifungal agents.

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