Related Experiment Video
Updated: Jun 22, 2026
08:22
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Dengue maculopathy: visual electrophysiology and optical coherence tomography
Thaís Sousa Mendes1, Edmundo Frota de Almeida Sobrinho, Alexandre Antonio Marques Rosa
1Instituto de Ciências Biológicas, Universidade Federal do Pará, Campus Universitário do Guamá, 66075-110, Belém, Pará, Brazil.
Documenta Ophthalmologica. Advances in Ophthalmology
|June 19, 2009
Summary
Dengue fever can cause vision loss, detectable through electrophysiology and retinal imaging. These tests reveal abnormalities in retinal function and structure, indicating potential maculopathy.
Area of Science:
- Ophthalmology
- Neuroscience
- Infectious Diseases
Background:
- Dengue fever is a mosquito-borne viral infection with potential systemic complications.
- Visual impairment following dengue infection, termed dengue maculopathy, requires further investigation.
- Ophthalmological and electrophysiological assessments are crucial for understanding visual pathway involvement.
Observation:
- Three female patients with post-dengue low visual acuity were evaluated.
- Assessments included routine ophthalmological exams, transient pattern electroretinogram (tPERG), transient pattern visual evoked cortical potential (tPVECP), and optical coherence tomography (OCT).
- Patients presented with reduced visual acuity and visual field defects (scotomata).
Findings:
- tPERG showed reduced or absent components in two patients, with unreliable data in the third.
- tPVECP at 0.5 cycles per degree (cpd) was normal, but at 2 cpd, one patient had absent components.
- OCT revealed abnormalities in two patients, including altered reflectivity and reduced retinal thickness.
Implications:
- Dengue fever can lead to significant visual impairment affecting retinal and cortical function.
- Electrophysiology (tPERG, tPVECP) and OCT are valuable tools for diagnosing dengue-related visual dysfunction.
- Dengue maculopathy, potentially due to vascular or immune issues, may cause temporary or permanent vision loss.
More Related Videos
Related Concept Videos
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...