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Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Updated: Jun 22, 2026

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

microRNAs in CNS disorders.

Jannet Kocerha¹, Sakari Kauppinen, Claes Wahlestedt

¹Department of Molecular and Integrative Neurosciences, Scripps Research Institute, Jupiter, FL 33458, USA.

Neuromolecular Medicine

|June 19, 2009

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in the central nervous system (CNS), impacting neuronal function and brain development. Dysregulation of these non-coding RNAs is linked to CNS disorders like Alzheimer's and schizophrenia.

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Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Recent advances in sequencing reveal the importance of non-coding RNAs, particularly microRNAs (miRNAs), in gene regulation.
Hundreds of miRNAs are present in the mammalian central nervous system (CNS), playing critical roles in neuronal functions and brain development.
miRNA dysregulation is implicated in various CNS disorders due to their ability to influence numerous downstream mRNA targets.

Purpose of the Study:

To provide an overview of current research on miRNAs in CNS disorders.
To highlight the pathogenic roles of specific miRNAs in diseases such as Alzheimer's disease and schizophrenia.
To discuss the application of locked nucleic acid (LNA)-modified oligonucleotides in miRNA detection and modulation.

Main Methods:

Review of recent scientific literature on miRNA research in CNS disorders.
Identification of key miRNAs and their downstream mRNA targets (e.g., BACE1, CaMKII) implicated in neurodegenerative and psychiatric conditions.
Exploration of LNA-modified oligonucleotides as tools for studying and manipulating miRNA activity.

Main Results:

miRNAs are integral to complex molecular networks essential for brain development and function.
Specific miRNAs have been identified with direct molecular and pathogenic roles in Alzheimer's disease and schizophrenia.
LNA-modified oligonucleotides show promise for both detecting and modulating miRNA activity.

Conclusions:

miRNAs represent a significant area of research for understanding and potentially treating CNS disorders.
Targeting specific miRNAs or their pathways could offer novel therapeutic strategies for neurological and psychiatric conditions.
LNA technology provides a valuable tool for advancing miRNA research and therapeutic development in the CNS.