Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of the Cardiovascular System

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...

Factors affecting Blood pressure

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polymorphisms of the angiotensin converting enzyme gene in relation to intrauterine growth restriction.

Acta obstetricia et gynecologica Scandinavica·2010

Same author

The beneficial effects of breastfeeding on microvascular function in 11- to 14-year-old children.

Vascular medicine (London, England)·2009

Same author

Correlation of angiotensin converting enzyme activity and the genotypes of the I/D polymorphism in the ACE gene with preterm birth and birth weight.

European journal of obstetrics, gynecology, and reproductive biology·2008

Same author

The influence of mode of delivery and ACE genotype on serum angiotensin converting enzyme (ACE) activity in the mother and infant at term.

European journal of obstetrics, gynecology, and reproductive biology·2006

Same author

The Walker Project: a longitudinal study of 48,000 children born 1952-1966 (aged 36-50 years in 2002) and their families.

Paediatric and perinatal epidemiology·2004

Same author

Impaired microvascular function in normal children: effects of adiposity and poor glucose handling.

The Journal of physiology·2003

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Do LCPUFAs influence cardiovascular function in early childhood?

J Stewart Forsyth¹

¹Ninewells Hospital and Medical School, Dundee, Scotland. stewartforsyth@nhs.net

Advances in Experimental Medicine and Biology

|June 19, 2009

Summary

Breast milk intake in infancy may lower childhood blood pressure. Long chain polyunsaturated fatty acids (LCPUFAs) in breast milk are a potential mechanism, with infant LCPUFA supplementation linked to lower blood pressure in early childhood.

Related Experiment Videos

Last Updated: Jun 22, 2026

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Area of Science:

Pediatric Nutrition
Cardiovascular Health
Human Physiology

Background:

Emerging evidence suggests a link between infant breast milk consumption and reduced childhood blood pressure.
The precise biological mechanisms are not fully understood, but long chain polyunsaturated fatty acids (LCPUFAs) are a focus of investigation.
Studies in adults show n-3 fatty acid supplementation can lower blood pressure, but pediatric data are scarce.

Purpose of the Study:

To investigate the association between infant nutrition, specifically LCPUFA intake, and blood pressure levels in early childhood.
To synthesize current evidence regarding the role of LCPUFAs in the relationship between breastfeeding and blood pressure.
To highlight the limited but suggestive data from randomized controlled trials in infants.

Main Methods:

Review of existing literature on infant feeding practices and childhood blood pressure.
Analysis of findings from randomized controlled studies on LCPUFA supplementation in infancy.
Examination of adult studies on n-3 fatty acid supplementation and blood pressure.

Main Results:

Two randomized controlled studies indicate that LCPUFA supplementation during infancy may be associated with lower blood pressure in early childhood.
While adult data support a blood pressure-lowering effect of n-3 fatty acids, direct evidence in children remains limited.
The potential role of LCPUFAs as a mediator between breast milk intake and blood pressure is an area of ongoing research.

Conclusions:

Infant LCPUFA intake, potentially through breast milk or supplementation, may contribute to lower blood pressure in childhood.
Further research is warranted to elucidate the mechanisms and confirm the long-term cardiovascular benefits of LCPUFA exposure in infancy.
Targeted nutritional interventions focusing on LCPUFAs in infancy could represent a strategy for promoting cardiovascular health from an early age.