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Related Experiment Video

Updated: Jun 22, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

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Published on: October 25, 2015

Epigenetics - potential contribution to fetal programming.

John C Mathers¹, Jill A McKay

¹Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, William Leech Building, Newcastle on Tyne, UK. john.mathers@newcastle.ac.uk

Advances in Experimental Medicine and Biology

|June 19, 2009

Summary

This summary is machine-generated.

Maternal diet influences offspring epigenetics, affecting gene expression and lifelong health. Understanding these epigenetic marks is crucial for nutrition and developmental origins of health research.

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Area of Science:

Epigenetics and Molecular Biology
Nutritional Science
Developmental Biology

Background:

Gene expression is influenced by DNA sequence and epigenetic modifications.
Epigenetic marks, such as DNA methylation and histone modifications, regulate genome packaging and accessibility.
These marks are dynamic, responding to environmental factors and contributing to phenotypic plasticity.

Purpose of the Study:

To investigate the impact of maternal diet on the epigenome.
To understand how epigenetic modifications influence gene expression patterns.
To explore the role of epigenetics in the developmental origins of health and disease.

Main Methods:

Analysis of epigenetic marks (DNA methylation, histone modifications) in offspring.
Assessment of gene expression patterns in relation to maternal diet.
Longitudinal studies tracking health outcomes throughout the life-course.

Main Results:

Maternal diet significantly alters epigenetic marking of the genome.
Altered epigenetic marks correlate with changes in offspring gene expression.
Evidence suggests a link between maternal diet-induced epigenetics and lifelong health trajectories.

Conclusions:

Maternal diet is a critical factor in shaping the epigenome.
Epigenetic mechanisms mediate the influence of early-life nutrition on health.
Further research into epigenetic alterations is vital for understanding nutrition's role in health and disease prevention.