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Updated: Jun 22, 2026
Primary Culture of Human Vestibular Schwannomas
Published on: July 20, 2014
Primary schwannoma in a cervical lymph node
Jennifer O Black1, Qihui Jim Zhai, Orlando B Varona
1Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, The Methodist Hospital, Houston, Texas, USA.
Background:
Spindle cell neoplasms within lymph nodes are rare and include benign and malignant tumors and primary and metastatic tumors such as palisaded myofibroblastoma, leiomyoma, leiomyosarcoma, reticular cell neoplasms, and vascular sarcomas. Ancillary studies may help distinguish these neoplasms.
Methods:
A 77-year-old white woman was seen with a painless, slowly growing mass of the left neck. Her clinical history was noncontributory. An excisional biopsy was performed without complication. There has been no recurrence, to date, of the lesion.
Results:
Gross examination, microscopic examination, immunohistochemistry, and ultrastructural studies were consistent with the diagnosis of schwannoma arising within a lymph node.
Conclusions:
We report the first case of intranodal schwannoma arising in a cervical lymph node. The recognition of intranodal schwannoma is important because it is cured with excision, whereas some of the other diagnostic considerations for a spindle cell lesion within a lymph node may require radiation or chemotherapy.
