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Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human
T Kanazu1, M Shinoda, T Nakayama
1Department of Biochemistry, Gifu Pharmaceutical University, Japan.
The Biochemical Journal
|November 1, 1991
Abstract:
3-Deoxyglucosone reductase activity in the extracts of rat, pig and human livers was potently inhibited by aldehyde reductase inhibitors. The major species of 3-deoxyglucosone reductase purified from human and pig livers were biochemically and immunochemically identical with aldehyde reductase. The two enzymes and rat liver aldehyde reductase exhibited higher catalytic efficiency for 3-deoxyglucosone than for D-glucuronate, a representative substrate of aldehyde reductase.