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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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Published on: June 9, 2018

[Renal amyloidosis during Behçet's disease. Study of one case]

Samira Azzabi1, Lamia Ben Hassine, Eya Cherif

  • 1Service de Médecine Interne B, Hôpital Charles Nicolle, Tunis, Tunisie.

La Tunisie Medicale
|June 20, 2009
PubMed
Abstract

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...