[Significance of atopic diathesis in atopic diseases prediction]

Atopy is a complex disorder characterized by affinity for elevated titre of IgE antibodies against one or more ubiquitous antigens, by the joint respiratory and skin manifestations, that is caused by an individual gene structure. Urticaria is a monomorphous dermatosis meaning a short-lived eruption of urticaria, characterized by circumscript edema of superficial dermis.

The objective of this study was to establish a participation of atopic genesis in the examined groups, on the basis of the questionnaire results.

The study involved 184 subjects, 10-60 years old, divided into the group with atopic diseases (70), the group with chronic urticaria (66), and the group with healthy controls (48). The questionnaire contained data on the family and personal history, clinical symptoms (dry skin, sneezing, eye-tearing, heavy breathing, etc.), and total IgE values in periphery blood. Each of these symptoms was qualified by curtain number of points (0.5-2), and the testees were classified into the groups according to the total score: with no atopic diathesis (0-8), unclear atopic diathesis (8-12), probable atopic diathesis (12-16), and clear atopic diathesis (over 16 points).

atopic diathesis (probable and clear) was confirmed in 70% of subjects in the atopic disease group, in 27.3% subjects with chronic urticaria, while in the healthy controls atopic diathesis was not registered (probable and clear).Statistical significance is present between atopic diseases group (15.4 +/- 3.6) and the rest of groups (8.8 +/- 3.9) according to the total score values in the questionnaire (p < 0.0001).

Atopic diathesis monitoring used in our study was proved as a good method for atopy recognition, that is confirmed statistically, as well. The score value was tested by the logistic regression, which enabled a possibility of atopic diseases prediction on the basis of the total score value from the questionnaire.