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Lubiprostone: in constipation-predominant irritable bowel syndrome
Natalie J Carter1, Lesley J Scott
1Wolters Kluwer Health, Adis, Auckland, New Zealand. demail@adis.co.nz
Drugs
|June 23, 2009
Summary
Lubiprostone effectively treats constipation-predominant irritable bowel syndrome (IBS-C) by increasing fluid secretion. Clinical trials showed significant symptom improvement with lubiprostone, and it was generally well-tolerated.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Lubiprostone is an oral medication that activates chloride channels in the gastrointestinal tract.
- This action increases fluid secretion, potentially improving constipation symptoms.
Purpose of the Study:
- To evaluate the efficacy and safety of lubiprostone in patients with constipation-predominant irritable bowel syndrome (IBS-C).
Main Methods:
- Large-scale, randomized, double-blind, placebo-controlled, multicenter Phase II and III trials were conducted.
- Patients received lubiprostone 8 microg twice daily for 3 months.
- A 4-week withdrawal period was included to assess symptom rebound.
Main Results:
- Significantly more patients receiving lubiprostone achieved an overall treatment response compared to placebo.
- Discontinuation of lubiprostone did not lead to a rebound of IBS symptoms.
- Lubiprostone was generally well-tolerated, with mild to moderate adverse events; nausea was most common.
Conclusions:
- Oral lubiprostone is an effective treatment for IBS-C.
- The medication demonstrates a favorable safety profile with no serious treatment-related adverse events reported.
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