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Updated: Jun 22, 2026
A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
Published on: November 18, 2022
A 90-day subchronic toxicity study of beta-calcium pyrophosphate in rat
Jae Hyup Lee1, Bong-Soon Chang, Hyun-Seung Ryu
1Department of Orthopedic Surgery, Seoul National University, College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
Abstract:
beta-calcium pyrophosphate has been used as a bone-graft extender. The present study evaluated the toxicity from the subchronic administration of beta-calcium pyrophosphate to male and female Sprague-Dawley rats. Animals were divided into two groups consisting of 10 male and 10 female rats each and fed beta-calcium pyrophosphate extract (30 mg/kg body weight/day) and saline, 7 days per week for 90 consecutive days. During the experiment, no deaths were observed in any groups, and there were no remarkable changes in clinical signs, body weight, food and water consumption, hematological and serum biochemical parameters, organ weight, and histopathological findings between the control and treated groups. The results show no adverse toxic effects of beta-calcium pyrophosphate extract (30 mg/kg body weight/day) for rats of either sex.
