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Acute Inflammation II: Cellular Phase

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The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

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Related Experiment Video

Updated: Jun 22, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Leukocyte-endothelial interactions in inflammation.

Harald F Langer¹, Triantafyllos Chavakis

¹Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD, USA. langerh@mail.nih.gov

Journal of Cellular and Molecular Medicine

|June 23, 2009

Summary

Leukocyte and platelet interactions with the endothelium are crucial for innate immunity during inflammation. This review details the molecular mechanisms governing these adhesive and transmigration processes.

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Last Updated: Jun 22, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

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Published on: December 30, 2014

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Area of Science:

Immunology
Cell Biology
Vascular Biology

Background:

Inflammation, infection, and vascular injury trigger leukocyte recruitment to endothelium.
Leukocyte-endothelial interactions are a multi-step cascade involving adhesion and transmigration.
Platelets contribute to inflammation by facilitating leukocyte-endothelial interactions.

Purpose of the Study:

To summarize key mechanisms and molecules in leukocyte-endothelial interactions.
To review the role of platelets in inflammatory pathologies.
To elucidate the molecular basis of leukocyte transmigration.

Main Methods:

Review of existing literature on leukocyte-endothelial and platelet interactions.
Analysis of molecular mediators like selectins and integrins.
Examination of transmigration routes (transcellular and paracellular).

Main Results:

Selectins mediate initial leukocyte rolling.
Chemokine-activated integrins cause firm leukocyte adhesion.
Leukocytes transmigrate via transcellular or paracellular routes.
Platelets enhance leukocyte-endothelial interactions.

Conclusions:

Leukocyte-endothelial and leukocyte-platelet interactions are vital for innate immunity in inflammation.
Understanding these interactions offers therapeutic targets for inflammatory diseases.
Platelet involvement highlights their multifaceted role in inflammatory responses.