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Updated: Jun 22, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Immune cells and angiogenesis.

Domenico Ribatti¹, Enrico Crivellato

¹Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it

Journal of Cellular and Molecular Medicine

|June 23, 2009

Summary

This summary is machine-generated.

Immune cells drive tissue vascularization by releasing pro-angiogenic factors, influencing inflammation and tumor growth. Their anti-angiogenic potential offers therapeutic strategies for cancer and inflammatory diseases.

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Area of Science:

Immunology
Angiogenesis research
Cell biology

Background:

Immune cells play a crucial role in regulating endothelial cell functions.
Pro-angiogenic mediators released by immune cells promote tissue vascularization.
Angiogenesis is a complex process involving a balance of regulatory factors.

Purpose of the Study:

To review the role of immune cells in angiogenesis during inflammation and tumor growth.
To explore the anti-angiogenic properties of immune cells for therapeutic applications.

Main Methods:

Literature review focusing on immune cell involvement in angiogenesis.
Analysis of pro- and anti-angiogenic mediators produced by immune cells.
Examination of the role of the immune microenvironment in vascularization.

Main Results:

Both innate and adaptive immune cells contribute to endothelial cell proliferation, migration, and activation.
Immune cells release a wide array of pro-angiogenic factors, fostering tissue vascularization.
Immune cells also possess anti-angiogenic properties with potential pharmacological value.

Conclusions:

Immune cells are key players in the angiogenic process in both inflammation and cancer.
Understanding the dual role of immune cells in angiogenesis can lead to novel therapeutic strategies.
Targeting immune cell-derived mediators may offer new avenues for anti-angiogenic therapies.