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Published on: March 23, 2018
Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes
Yutaka Yoshikawa1, Ryoko Hirata, Hiroyuki Yasui
1Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. yutaka@mb.kyoto-phu.ac.jp
Abstract:
We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects.
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