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Updated: Jun 22, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: intimate relationships
Melissa A Landek-Salgado1, Angelika Gutenberg, Isabella Lupi
1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Abstract:
Autoimmune diseases comprise a group of about 85 heterogeneous conditions that can affect virtually any organ and tissue in the body. Many autoimmune diseases change significantly during pregnancy: some ameliorate, some worsen, and others are unaffected. Two autoimmune diseases present prominently in relation to pregnancy: postpartum autoimmune thyroiditis and autoimmune hypophysitis. This article will review the current state of knowledge of the immunological changes that occur during normal pregnancy, and will explore the striking temporal association with pregnancy observed in thyroiditis and hypophysitis.
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