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Synthesis and antimicrobial activity of hydroxy-isophthalaldehyde acid derivatives
E Piscopo1, M V Diurno, O Mazzoni
1Departimento di Chimica Farmaceutica e Tossicologica Università di Napoli Federico II, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|May 1, 1991
Abstract:
4-hydroxy-isophthalaldehyde acid (1), its alkyl esters (methyl, ethyl, propyl and butyl) and alkyl ethers (propyl, butyl, pentyl and esyl), as well as 6-hydroxy-isophthalaldehyde acid (2) ita alkyl esters (methyl and ethyl), 4-hydroxy-5-iodo-isophthalaldehyde acid (3) and its methyl ester were synthesized and characterized. Antimicrobial and antifungal activity was tested and the LD50 of the most active compound 4 was determined.