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Updated: Jun 22, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target

Zhaocai Zhou1, Xiaomin Song, Alan Berezov

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

International Immunopharmacology
|June 23, 2009
PubMed

Insights

The transcription factor FOXP3 is crucial for immune balance. Understanding its complex interactions offers new avenues for treating immune diseases like autoimmunity and cancer.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • The transcription factor FOXP3 is essential for immune homeostasis and the function of regulatory T cells (Tregs).
  • Dysfunction of FOXP3 in Tregs is implicated in various diseases, including autoimmunity, cancer, and viral infections.
  • FOXP3 operates within dynamic regulatory complexes, influencing gene expression critical for immune responses.

Purpose of the Study:

  • To elucidate the structural and biochemical mechanisms of FOXP3 function within Tregs.
  • To gain insights into how FOXP3 acts as a transcriptional repressor or activator.
  • To inform the development of novel immunopharmacological agents for immunological diseases.

Main Methods:

  • Structural and biochemical analyses of the FOXP3 complex ensemble.
  • Investigation of FOXP3 interactions with other transcriptional factors, co-repressors, and co-activators.
  • Study of signaling pathways modulated by FOXP3 complexes.

Main Results:

  • Provided structural and biochemical insights into the FOXP3 complex ensemble.
  • Detailed the interactions of FOXP3 with regulatory partners within Tregs.
  • Highlighted the role of these complexes in modulating key signaling pathways.

Conclusions:

  • Understanding the FOXP3 complex is vital for comprehending Treg function in immune homeostasis.
  • These findings are essential for developing new therapeutic strategies targeting immunological diseases.
  • FOXP3 complex insights pave the way for novel immunopharmacological agents.

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