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Published on: August 13, 2013
MicroRNAs and immune regulatory T cells
Li Zhou1, Kook Heon Seo, Henry K Wong
1Henry Ford Hospital Immunology Program, Henry Ford Hospital, Detroit, MI, USA.
Abstract:
MicroRNAs (miRNAs)-mediated RNA interference are emerging as an important regulatory pathway for various biological processes, including development, differentiation, and homeostasis. Accumulated evidence suggests that miRNAs regulate T cell and B cell differentiation, proliferation, and apoptosis. Deletion of miRNAs in hematopoietic stem cells or in thymus disrupts T cell homeostasis and results in autoimmunity and abnormal cytokine production. Regulatory T cells are potent immune regulators. In this mini-review, we provide a brief overview of the important roles of miRNAs in the development and function of T cells, especially in immune regulatory T cells.
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