Reversible pathologic jealousy (Othello syndrome) associated with amantadine

Area of Science:

• Neuroscience
• Psychiatry
• Movement Disorders

Background:

• Parkinson disease (PD) is a neurodegenerative disorder affecting motor function.
• Behavioral changes, including psychosis and impulse control disorders, can occur in PD.
• Amantadine is a medication used to manage PD symptoms like dyskinesia.

Observation:

• A patient with Parkinson disease developed pathologic jealousy (Othello syndrome).
• The Othello syndrome symptoms resolved after the patient discontinued amantadine treatment.
• This suggests a potential link between amantadine and the onset of delusional jealousy.

Findings:

• Discontinuation of amantadine led to the abatement of Othello syndrome in the described Parkinson disease case.
• The case report suggests a correlation between dopaminergic activity modulation and the emergence of pathologic jealousy.
• Early identification and management of Othello syndrome in Parkinson disease patients are crucial.

Implications:

• Recognizing and treating Othello syndrome early in Parkinson disease patients may prevent physical violence.
• This case highlights the importance of considering medication side effects in behavioral changes in PD.
• Further research is warranted to explore the relationship between dopaminergic agents and delusional jealousy in neurodegenerative conditions.