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Updated: Jun 22, 2026
09:29
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
Neuronal intermediate filaments and neurodegenerative disorders
1Department of Anatomy and Physiology of Laval University, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada.
Brain Research Bulletin
|June 23, 2009
Summary
Abnormalities in neuronal intermediate filaments are linked to neurodegenerative diseases. While some protein aggregates may offer protection, the mechanisms causing these changes remain unclear.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Intermediate filaments are the most abundant cytoskeletal components in mature neurons.
- Mutations and accumulations of neuronal intermediate filament proteins are implicated in neurodegenerative disorders.
- Disorganization of the neurofilament network is recognized as a factor in neurodegeneration, though protective roles of certain aggregates exist.
Purpose of the Study:
- To review neurodegenerative diseases associated with intermediate filament abnormalities.
- To explore potential mechanisms underlying the formation of these protein aggregates.
Main Methods:
- Review of existing literature on neurodegenerative diseases and intermediate filaments.
- Analysis of data from various mouse models investigating intermediate filament roles.
Main Results:
- Intermediate filament disorganization is a common feature in neurodegenerative pathogenesis.
- Specific perikaryal intermediate filament aggregates may provide a protective effect in certain conditions, such as motor neuron disease.
- Mouse models have enhanced understanding of intermediate filament involvement.
Conclusions:
- Intermediate filament abnormalities are significant in neurodegenerative disease.
- The precise mechanisms driving aggregate formation require further elucidation.
- Further research is needed to understand the dual role of intermediate filaments in neurodegeneration.
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