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Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
Published on: October 25, 2024
Cryoprecipitate: the current state of knowledge.
Jeannie L Callum1, Keyvan Karkouti, Yulia Lin
1Sunnybrook Health Sciences Centre and University Health Network, Toronto, Ontario, Canada. jeannie.callum@sunnybrook.ca
Transfusion Medicine Reviews
|June 23, 2009
Summary
Cryoprecipitate is widely used but lacks sufficient evidence for optimal use in massive hemorrhage and hypofibrinogenemia. Further research is needed to establish its efficacy, safety, and best transfusion strategies.
Area of Science:
- Transfusion Medicine
- Hematology
Background:
- Cryoprecipitate is a complex blood product with multiple hemostatic factors.
- Its clinical efficacy and optimal use, particularly in massive hemorrhage, remain understudied.
Purpose of the Study:
- To review the current understanding of cryoprecipitate's role in hemostasis.
- To identify knowledge gaps regarding its clinical application, efficacy, safety, and optimal administration.
Main Methods:
- Literature review of studies on cryoprecipitate use.
- Analysis of current clinical practices and indications.
Main Results:
- Cryoprecipitate contains Factor VIII, von Willebrand factor, fibrinogen, fibronectin, Factor XIII, and platelet microparticles.
- Insufficient data exist on efficacy, safety, and dosage for hypofibrinogenemia in massive hemorrhage.
- Optimal pooling and transfusion strategies require further investigation.
Conclusions:
- Despite extensive use, optimal cryoprecipitate administration and its role in managing hypofibrinogenemia require significant further research.
- Evidence-based guidelines for cryoprecipitate use are lacking.
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