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Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

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Published on: November 8, 2018

[Convulsions following dialysis sessions].

M-L Atse¹, O Le Bon, J-M Des Grottes

¹Service de psychiatrie, CHU Tivoli, 39, avenue Max-Buset, 7100 La-Louvière, Belgique.

|June 23, 2009

Summary

A patient with bipolar disorder experienced seizures after dialysis due to lithium toxicity affecting their kidneys. Treatment adjustments successfully resolved these seizure events, highlighting the importance of medication management in renal complications.

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Area of Science:

Nephrology
Psychiatry
Clinical Toxicology

Background:

Lithium is a mood stabilizer commonly used in bipolar disorder treatment.
Renal angiosclerosis is a condition characterized by hardening of the kidney arteries.
Lithium intoxication can lead to various adverse effects, including renal complications.

Observation:

A patient with bipolar disorder presented with renal angiosclerosis attributed to lithium intoxication.
The patient experienced recurrent convulsive crises following each hemodialysis session for approximately four months.
Standard etiological workup did not identify a singular cause for the persistent seizures.

Findings:

The convulsive crises were temporally associated with hemodialysis sessions in a patient with lithium-induced renal angiosclerosis.
Despite extensive investigation, a definitive cause for the post-hemodialysis seizures remained elusive.
Modifications in the patient's treatment regimen led to the cessation of seizure activity.

Implications:

This case underscores the potential for severe renal complications, such as angiosclerosis, from chronic lithium use.
The management of bipolar disorder requires careful monitoring for lithium toxicity and its impact on renal function.
Treatment adjustments, potentially involving medication changes or dialysis protocols, can effectively manage complex lithium-related adverse events.