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Published on: June 20, 2019
Synthesis and self-assembly of amphiphilic hyperbranched polyglycerols modified with palmitoyl chloride
Haixing Cheng1, Siguang Wang, Jintian Yang
1College of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China.
Abstract:
A series of palmitoyl chloride-grafted hyperbranched polyglycerols were synthesized through cationic ring-opening polymerization and end-group modification. The obtained grafted copolymer of HPG-C16 possesses a hydrophilic hyperbranched polyether core and many hydrophobic alkyl arms, which shows interesting self-assembly behavior in THF and water. The results indicate that the copolymers with a relatively high alkyl grafting ratio can form unimolecular micelles in THF and will further assemble into giant vesicles around 1-10 microm in THF/water mixed solvents. However, the HPG-C16 with a low alkyl grafting ratio of 15.6% can directly assemble into vesicles in THF and form micelles in water.
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