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Updated: Jun 22, 2026

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
Published on: June 8, 2022
Myositis associated with localized lipodystrophy: an unrecognized condition?
Hans-Jürgen Gdynia1, P Weydt, A Ernst
1Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. hans-juergen.gdynia@uni-ulm.de
Abstract:
Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association with localized lipodystrophy. Immunohistochemical stainings revealed a regular pattern of dystrophin, dysferlin, sarcoglycans, and theletonin. Furtermore, there was no evidence of Lamin A/C deficiency. A nearly identical clinical and histological picture has been described in three patients up to now. Although it is difficult to speculate on a causative pathophysiological mechanism at this time, it is possible that this association represents an unrecognized condition.
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